PGT-A Testing in Dubai: The Science Behind Healthier Pregnancies

In vitro fertilization (IVF) has revolutionized reproductive medicine, offering hope to couples struggling with infertility. However, the success of IVF largely depends on the quality of the embryos transferred. Preimplantation Genetic Testing for Aneuploidy (PGT-A) has emerged as a powerful tool to enhance IVF success rates by selecting embryos with the correct number of chromosomes. In Dubai, where advanced reproductive technologies are widely available, PGT-A is becoming an increasingly popular option for couples seeking healthier pregnancies.

What is PGT-A Testing? An Overview of Genetic Screening

PGT-A is a genetic screening test used during IVF to analyze embryos for chromosomal abnormalities. Normally, human cells contain 46 chromosomes—23 from the egg and 23 from the sperm. If an embryo has too few or too many chromosomes, it can lead to failed implantation, miscarriage, or genetic conditions such as Down syndrome. PGT-A helps embryologists identify embryos with the correct chromosomal composition before implantation. By selecting only euploid (chromosomally normal) embryos, the chances of a successful pregnancy increase significantly. This testing does not diagnose specific genetic disorders but focuses on chromosomal count and structure, ensuring a healthier start to pregnancy.

How PGT-A Improves IVF Success Rates

IVF success rates depend on multiple factors, including the age of the patient, egg and sperm quality, and embryo viability. One of the main reasons for IVF failure is embryo aneuploidy, where the embryo has an abnormal number of chromosomes. PGT-A reduces this risk by screening for abnormalities before transfer. By selecting euploid embryos, PGT-A improves implantation rates, reduces the risk of miscarriage, and increases the likelihood of a healthy pregnancy. Studies show that using PGT-A can raise IVF success rates to 60-70% per transfer, compared to lower rates in conventional IVF without genetic screening. This technology is particularly beneficial for couples who have experienced multiple failed IVF cycles or recurrent pregnancy loss.

Who Should Consider PGT-A Testing?

PGT-A testing is not mandatory but is highly recommended for specific groups of patients undergoing IVF. Couples who may benefit from PGT-A include:

• Women over 35: The risk of chromosomal abnormalities increases with maternal age, making genetic screening crucial for older patients.
• Couples with recurrent miscarriages: Many miscarriages occur due to chromosomal abnormalities, and PGT-A can help prevent this by ensuring only healthy embryos are implanted.
• Individuals with a history of failed IVF cycles: If previous IVF attempts have resulted in implantation failure, PGT-A can improve the chances of success.
• Patients with known chromosomal rearrangements: Couples with conditions such as translocations or inversions may carry a higher risk of producing abnormal embryos.
• Those opting for single embryo transfer (SET): PGT-A allows for the selection of the best embryo, reducing the need for multiple transfers while maintaining high success rates.

While PGT-A offers clear benefits, it may not be necessary for every IVF patient. Consulting with a fertility specialist can help determine if genetic testing is the right choice based on individual medical history and reproductive goals.

The Process of PGT-A Testing in Dubai

PGT-A testing is integrated into the IVF process and involves several key steps:

• Ovarian Stimulation and Egg Retrieval: The first stage of IVF involves stimulating the ovaries with hormone medications to produce multiple eggs. These eggs are then retrieved through a minor surgical procedure.
• Fertilization and Embryo Culture: The retrieved eggs are fertilized with sperm in a laboratory to create embryos. The embryos are monitored for several days as they develop.
• Embryo Biopsy: On day five or six of development, a few cells are carefully extracted from the outer layer of the embryo (trophectoderm). This procedure is performed under a high-powered microscope and does not harm the embryo.
• Genetic Analysis: The extracted cells are sent to a specialized genetic laboratory, where they are analyzed for chromosomal abnormalities.
• Selection and Transfer: Only chromosomally normal embryos are selected for transfer. The healthiest embryo is then implanted into the uterus, while additional viable embryos can be frozen for future use.
• Pregnancy Testing: After 10-14 days, a blood test is conducted to determine if implantation was successful.

Finding the Right Fertility Clinic for PGT-A in Dubai

Choosing a fertility clinic is a critical step for couples considering IVF with PGT-A testing. Dubai is home to several world-class fertility centers equipped with cutting-edge technology and experienced specialists. When selecting a clinic, consider the following factors:

• Success Rates: Look for clinics with high IVF success rates, particularly for cases involving PGT-A.
• Accreditation and Licensing: Ensure that the clinic is licensed by the Dubai Health Authority (DHA) and follows international standards.
• Experience in Genetic Testing: Not all fertility centers offer PGT-A, so verify that the clinic has expertise in genetic screening.
• The best clinics offer a suite of fertility treatments, including advanced embryo monitoring methods, sperm analysis, and egg freezing.
• Undergoing IVF can be a trip of emotions. Select a clinic providing counseling and psychological support.

The Cost of PGT-A Testing in Dubai

The cost of PGT-A testing varies depending on the clinic, the number of embryos tested, and additional fertility treatments required. On average, PGT-A testing costs between AED 10,000 and AED 15,000, in addition to standard IVF expenses, which range from AED 25,000 to AED 40,000 per cycle.

Some clinics offer package deals that include IVF and PGT-A testing at a discounted rate. Although the initial outlay for genetic screening could seem expensive, by lowering the need for several IVF cycles and raising the possibility of a successful pregnancy on the first try, it can eventually save money.

The Future of PGT-A in Dubai

Advancements in reproductive technology continue to enhance the effectiveness of IVF and genetic screening. Emerging techniques, such as non-invasive PGT-A (niPGT-A), may soon replace traditional biopsy methods, making genetic testing safer and more accessible. Dubai remains at the forefront of fertility treatment, with ongoing research into artificial intelligence (AI) applications in embryo selection, improved genetic analysis techniques, and personalized IVF protocols. As these innovations continue to evolve, PGT-A will likely become an even more integral part of assisted reproductive technology.

Conclusion

For couples undergoing IVF, PGT-A testing is a useful tool providing better pregnancy results and lower miscarriage risk. Modern genetic screening offered by Dubai's sophisticated fertility clinics helps couples realize their aspirations of parenthood with more assurance.See a fertility specialist first for those contemplating PGT-A to help them make an informed choice. Couples have more chances of a successful and healthy pregnancy with the correct clinic and professional advice, so guaranteeing the best possible start for their future child.