Preimplantation Genetic Screening (PGS)

Preimplantation Genetic Screening (PGS)

PGS testing is done to enhance in vitro fertilization (IVF) cycles. The purpose of PGS is to increase the chance of becoming pregnant and lower the chance of miscarriage.

A PGS test reveals the number of chromosomes in one or a few cells from each embryo of an IVF cycle. Embryos with the normal number of chromosomes (46) have a better chance of implanting and are essential in creating a healthy pregnancy. After PGS testing, normal embryos can be selected for transfer to the mother’s uterus.

Choose the Right Embryo to Transfer
Aster IVF uses next generation sequencing (NGS), a testing method that provides outstanding accuracy. Pre-implantation genetic screening is performed by Aster IVF to screen for genetic defects in embryos prior to pregnancy. PGS is typically used with parents that are (or are assumed) to be genetically normal and want assurance that only genetically normal embryos are transferred following IVF.

Aster IVF screens for chromosomal abnormalities, which can result in aneuploidy, embryos having the incorrect number of chromosomes, and translocations, chromosomes that are incorrectly arranged. For example, an extra copy of chromosome 21 manifests as Down Syndrome. Once the embryos have been screened and deemed free of genetic defects, they can be placed in the uterus. Performing this pre-screening procedure may, under some circumstances, substitute for invasive procedures that sometimes occur during pregnancy such as chorionic villus sampling and amniocentesis. If a genetic defect is found during these post-conception procedures, parents are forced to make a difficult decision: whether to terminate a pregnancy or risk having a child with a genetic disease. Pre-screening procedures can avoid these difficult decisions.

Common Infertility Problems Addressed by PGS

  • Advanced maternal age
  • Unexplained infertility
  • History of miscarriage
  • Pregnancy failure
  • Carrier of genetic diseases (Visit our page on PGD)

 

Syndromes Detected by PGS

  • Patau Syndrome (+13)
  • Edwards syndrome (+18)
  • Down syndrome (+21)
  • Klinefelter syndrome (XXY)
  • Turner syndrome (XO)
  • XYY syndrome (XYY)

 

24-chromosome testing using NGS

Embryos are tested for the number of chromosomes using next generation sequencing (NGS). Chromosomes are assessed for copy number and large genetic deletions and insertions. Next generation sequencing provides higher accuracy and sensitivity compared to conventional methods, such as microarray.

Aster IVF uses NGS, the latest technology used in human genome sequencing, to provide the most reliable and accurate results for our clients.

Contact Us

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